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Phentermine (Suprenza), an appetite suppressant, Is the most widely prescribed medication for weight loss. The FDA has only approved its use for the short term (less than 12 weeks), but it is frequently prescribed off-label for longer.
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Phentermine, diethylpropion and phendimetrazine are all prescription medications your physician can prescribe for you that work by suppressing your appetite, according to The Weight-Control Information Network, part of the National Institutes of Health.